PROGINS polymorphism of progesterone receptor is increased in female offspring with maternal exposure to diethylstilbestrol.

@article{Engehausen2000PROGINSPO,
  title={PROGINS polymorphism of progesterone receptor is increased in female offspring with maternal exposure to diethylstilbestrol.},
  author={Dirk Gerhard Engehausen and Karl Michael Schrott},
  journal={Anticancer research},
  year={2000},
  volume={20 6D},
  pages={
          5145-9
        }
}
DES (Diethylstilbestrol) was used for the treatment of corpus luteum insufficiences in early pregnancy. Prenatal exposure to DES leads to an increased frequency of vaginal cancer in female offspring. DES causes persistent alterations of steroid hormone binding in the vaginal tissue. The frequency of a polymorphism (PROGINS) of human progesterone receptor (hPR) gene which is associated with an increased risk of sporadic ovarian cancer was tested in DES-exposed offspring with vaginal dysplasia… CONTINUE READING