PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145

@inproceedings{Yang2015PRMT9IA,
  title={PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145},
  author={Yanzhong Yang and Andrea Hadjikyriacou and Zheng Xia and Sitaram Gayatri and Daehoon Kim and Cecilia I. Zurita-Lopez and Ryan M Kelly and Ailan Guo and Wei Li and Steven G. Clarke and Mark T Bedford},
  booktitle={Nature communications},
  year={2015}
}
The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two spliceosome-associated proteins-SAP145 and SAP49-as PRMT9-binding partners, linking PRMT9 to U2 snRNP maturation. We show that SAP145 is methylated by PRMT9 at arginine 508, which takes the form of monomethylated arginine (MMA) and symmetrically dimethylated arginine (SDMA). PRMT9 thus joins PRMT5 as… CONTINUE READING
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SHOWING 1-10 OF 39 REFERENCES

Deep-sequencing data can be accessed with GEO accession number GSE63953

  • C. I. Sandberg T. Kelly R. Zurita-Lopez, S. G. Human protein arginine methyltransferase 7 is a Clarke, +7 authors S.G.C. provided valuable support with the writing. Additi codes
  • Supplementary Information accompanies this paper…
  • 2015

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs

  • S Dhar
  • Sci. Rep
  • 2013
1 Excerpt

A method for large-scale identification of protein arginine methylation

  • T Uhlmann
  • Mol. Cell Proteomics 11,
  • 2012

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