PRMT7 induces epithelial-to-mesenchymal transition and promotes metastasis in breast cancer.

@article{Yao2014PRMT7IE,
  title={PRMT7 induces epithelial-to-mesenchymal transition and promotes metastasis in breast cancer.},
  author={Ruosi Yao and Hao Jiang and Yuhui Ma and Lei Wang and Lin Wang and Juan Du and Pingfu Hou and Yanyan Gao and Lu Zhao and Guannan Wang and Yu Zhang and Dong-Xu Liu and Baiqu Huang and Jun Lu},
  journal={Cancer research},
  year={2014},
  volume={74 19},
  pages={5656-67}
}
Epithelial-to-mesenchymal transition (EMT) enables metastasis. E-cadherin loss is a hallmark of EMT, but there remains an incomplete understanding of the epigenetics of this process. The protein arginine methyltransferase PRMT7 functions in various physiologic processes, including mRNA splicing, DNA repair, and neural differentiation, but its possible roles in cancer and metastasis have not been explored. In this report, we show that PRMT7 is expressed at higher levels in breast carcinoma cells… CONTINUE READING
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