PRMT7 Preserves Satellite Cell Regenerative Capacity.

  title={PRMT7 Preserves Satellite Cell Regenerative Capacity.},
  author={Rom{\'e}o S{\'e}bastien Blanc and Gillian Vogel and Taiping Chen and Colin Crist and St{\'e}phane Richard},
  journal={Cell reports},
  volume={14 6},
Regeneration of skeletal muscle requires the continued presence of quiescent muscle stem cells (satellite cells), which become activated in response to injury. Here, we report that whole-body protein arginine methyltransferase PRMT7(-/-) adult mice and mice conditionally lacking PRMT7 in satellite cells using Pax7-CreERT2 both display a significant reduction in satellite cell function, leading to defects in regenerative capacity upon muscle injury. We show that PRMT7 is preferentially expressed… CONTINUE READING
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