PRMT5–PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells

@article{BanasavadiSiddegowda2017PRMT5PTENMP,
  title={PRMT5–PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells},
  author={Yeshavanth Kumar Banasavadi-Siddegowda and Lundholm Russell and Emma Frair and Vrajesh Karkhanis and Theresa Relation and Ji Young Yoo and Jiachang Zhang and Sa{\"i}d Sif and Jaime Imitola and Robert A Baiocchi and Balveen Kaur},
  journal={Oncogene},
  year={2017},
  volume={36},
  pages={263-274}
}
Glioblastoma (GBM) represents the most common and aggressive histologic subtype among malignant astrocytoma and is associated with poor outcomes because of heterogeneous tumour cell population including mature non-stem-like cell and immature stem-like cells within the tumour. Thus, it is critical to find new target-specific therapeutic modalities. Protein arginine methyltransferase enzyme 5 (PRMT5) regulates many cellular processes through its methylation activity and its overexpression in GBM… CONTINUE READING
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