PRMT3 regulates hepatic lipogenesis through direct interaction with LXRα.

@article{Kim2015PRMT3RH,
  title={PRMT3 regulates hepatic lipogenesis through direct interaction with LXRα.},
  author={Dong-Il Kim and Min-Jung Park and Seul-ki Lim and Jae-Il Park and Kyung-chul Yoon and Ho-Jae Han and Jan-{\AA}ke Gustafsson and Jae-hyang Lim and Soo-hyun Park},
  journal={Diabetes},
  year={2015},
  volume={64 1},
  pages={
          60-71
        }
}
Arginine methylation is responsible for diverse biological functions and is mediated by protein arginine methyltransferases (PRMTs). Nonalcoholic fatty liver disease (NAFLD) is accompanied by excessive hepatic lipogenesis via liver X receptor α (LXRα). Thus we examined the pathophysiological role of PRMTs in NAFLD and their relationship with LXRα. In this study, palmitic acid (PA) treatment increased PRMT3, which is correlated with the elevation of hepatic lipogenic proteins. The expression of… CONTINUE READING

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