PRL-induced ERalpha gene expression is mediated by Janus kinase 2 (Jak2) while signal transducer and activator of transcription 5b (Stat5b) phosphorylation involves Jak2 and a second tyrosine kinase.

Abstract

In the rat corpus luteum of pregnancy, PRL stimulation of ER expression is a prerequisite for E2 to have any luteotropic effect. Previous work from our laboratory has established that PRL stimulates ERalpha expression at the level of transcription and that the transcription factor Stat5 (signal transducer and activator of transcription 5) mediates this… (More)

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@article{Frasor2001PRLinducedEG, title={PRL-induced ERalpha gene expression is mediated by Janus kinase 2 (Jak2) while signal transducer and activator of transcription 5b (Stat5b) phosphorylation involves Jak2 and a second tyrosine kinase.}, author={Jonna M. Frasor and Uriel Barkai and Laura Zhong and Asgerally T. Fazleabas and Gil B Gibori}, journal={Molecular endocrinology}, year={2001}, volume={15 11}, pages={1941-52} }