PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo.

@article{Guo2006PRL3IT,
  title={PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo.},
  author={Ke Guo and J. Q. Li and Haihe Wang and Motomi Osato and Jing Tang and Samantha Yiling Quah and Bin Qi Gan and Qi Zeng},
  journal={Cancer research},
  year={2006},
  volume={66 19},
  pages={9625-35}
}
We show here that PRL-3 protein is expressed in fetal heart, developing blood vessels, and pre-erythrocytes but not in their mature counterparts. These observations imply that PRL-3 may be involved in the early development of the circulatory system. Because PRL-3 mRNA had been reported to be consistently elevated in metastatic samples derived from colorectal cancers, we attempted to investigate if PRL-3 might be involved in tumor angiogenesis and if PRL-3-expressing cells could cross-talk to… CONTINUE READING
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PRL-3 and PRL-1 Cancer

  • Q Zeng, JM Dong, K Guo
  • Research Cancer Res
  • 2006
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