PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition.

Abstract

PRL-3 is a metastasis-associated phosphatase. We and others have shown that its overexpression increases cell motility and invasiveness. These phenotypic changes are reminiscent of the epithelial-mesenchymal transition (EMT) that occurs during embryonic development and oncogenesis. The EMT is a complex process that converts epithelia into migratory… (More)

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