PRKACB and Carney complex.

@article{Forlino2014PRKACBAC,
  title={PRKACB and Carney complex.},
  author={Antonella Forlino and Annalisa Vetro and Livia Garavelli and Roberto Ciccone and Edra London and Constantine A. Stratakis and Orsetta Zuffardi},
  journal={The New England journal of medicine},
  year={2014},
  volume={370 11},
  pages={
          1065-7
        }
}
The authors report that a gain of function in the catalytic subunit beta of the cyclic AMP–dependent protein kinase (protein kinase A), resulting from the presence of four copies of PRKACB (instead of the normal two), may lead to a Carney complex phenotype. 
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How the PRKACA and PRKACB genes have developed as paralogs that encode distinct and functionally non-redundant proteins is discussed to open new windows for PKA-induced disease pathologies.
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