PRKACA Mediates Resistance to HER2-Targeted Therapy in Breast Cancer Cells and Restores Anti-Apoptotic Signaling

@inproceedings{Moody2015PRKACAMR,
  title={PRKACA Mediates Resistance to HER2-Targeted Therapy in Breast Cancer Cells and Restores Anti-Apoptotic Signaling},
  author={Susan E. Moody and Anna C. Schinzel and Satish Kumar Singh and Fiorentino Izzo and Marie Strickland and Leo Y Luo and S R Thomas and Jesse S Boehm and Sanghoon Kim and Zhongxiao Wang and William C. Hahn},
  booktitle={Oncogene},
  year={2015}
}
Targeting HER2 with antibodies or small molecule inhibitors in HER2-positive breast cancer leads to improved survival, but resistance is a common clinical problem. To uncover novel mechanisms of resistance to anti-HER2 therapy in breast cancer, we performed a kinase open reading frame screen to identify genes that rescue HER2-amplified breast cancer cells from HER2 inhibition or suppression. In addition to multiple members of the MAPK (mitogen-activated protein kinase) and PI3K… CONTINUE READING
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