PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells

@inproceedings{Jilg2014PRK1PKN1CM,
  title={PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells},
  author={Cordula Annette Jilg and Anett Ketscher and Eric Metzger and B{\'a}rbara Hummel and Dominica Willmann and Vanessa R{\"u}sseler and Vanessa Drendel and Axel Imhof and Manfred Jung and Henriette Franz and Stefanie H{\"o}lz and Malte Kroenig and Judith M M{\"u}ller and Roland Sch{\"u}le},
  booktitle={Oncotarget},
  year={2014}
}
The major threat in prostate cancer is the occurrence of metastases in androgen-independent tumor stage, for which no causative cure is available. Here we show that metastatic behavior of androgen-independent prostate tumor cells requires the protein-kinase-C-related kinase (PRK1/PKN1) in vitro and in vivo. PRK1 regulates cell migration and gene expression through its kinase activity, but does not affect cell proliferation. Transcriptome and interactome analyses uncover that PRK1 regulates… CONTINUE READING

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