PRIMA-1 inhibits growth of breast cancer cells by re-activating mutant p53 protein.

@article{Liang2009PRIMA1IG,
  title={PRIMA-1 inhibits growth of breast cancer cells by re-activating mutant p53 protein.},
  author={Yayun Liang and Cynthia Lee Besch-Williford and Salman M. Hyder},
  journal={International journal of oncology},
  year={2009},
  volume={35 5},
  pages={
          1015-23
        }
}
Mutation of the p53 tumor suppressor gene is a common event in many types of tumors, including breast cancers. Mutant p53 (mtp53) protein is thought to promote tumor cell survival and resistance to chemotherapeutic drugs. Therefore, restoring p53 function by converting existing mtp53 to the wild-type p53 (wtp53) conformation is being pursued as one strategy to promote apoptosis of tumor cells. PRIMA-1 (p53 re-activation and induction of massive apoptosis) is a non-toxic small molecule that… CONTINUE READING

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