PRG-1 transcriptional regulation independent from Nex1/Math2-mediated activation

@article{Geist2011PRG1TR,
  title={PRG-1 transcriptional regulation independent from Nex1/Math2-mediated activation},
  author={Beate Geist and Brita Vorwerk and Pierluca Coiro and Olaf Ninnemann and Robert Nitsch},
  journal={Cellular and Molecular Life Sciences},
  year={2011},
  volume={69},
  pages={651-661}
}
Plasticity-related gene 1 (PRG-1) is a novel player in glutamatergic synaptic transmission, acting by interfering with lysophosphatidic acid (LPA)-dependent signaling pathways. In the central nervous system, PRG-1 expression is restricted to postsynaptic dendrites on glutamatergic neurons. In this study, we describe the promoter architecture of the PRG-1 gene using RNA ligase-mediated rapid amplification of cDNA ends (RLM-Race) and PCR analysis. We found that PRG-1 expression is under the… CONTINUE READING