• Corpus ID: 55971138

PREX1 regulates ERK1/2 in breast cancer

  title={PREX1 regulates ERK1/2 in breast cancer},
  author={Heng-Jia Liu and Lisa M. Ooms and Nuthasuda Srijakotre and Joey Man and Jessica L. Vieusseux and Emerman Joanne and Waters and Yue Feng and Charles G Bailey and J. E. J. Rasko and John T Price and A. Christina and Mitchell},
PREX1 (PtdIns(3,4,5)P3-dependent Rac exchanger 1), is a Rac-GEF overexpressed in a significant proportion of human breast cancers that integrates signals from upstream ErbB2/3 and CXCR4 membrane surface receptors. However, the PREX1 domains that facilitate its oncogenic activity and downstream signaling are not completely understood. We identify ERK1/2 mitogen-activated protein kinase (MAPK) acts downstream of PREX1 and contributes to PREX1mediated anchorage independent cell growth. PREX1… 


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