PREVENTION OF EPILEPSY BY LOW-DOSE ARTESUNATE + ESOMEPRAZOLE-FUROSEMIDE SEQUENTIAL THERAPY.

@inproceedings{Oriaifo2017PREVENTIONOE,
  title={PREVENTION OF EPILEPSY BY LOW-DOSE ARTESUNATE + ESOMEPRAZOLE-FUROSEMIDE SEQUENTIAL THERAPY.},
  author={S. E. Oriaifo},
  year={2017}
}
Very recent findings indicate an important neuromodulatory role for astrocytes in altering neural circuit activity and behaviour. Artesunate, esomeprazole and furosemide are now verified agents that modulate noxious agents-induced hazardous orchestra via ATPP2X7R-P2YINLRP3-A2AR signalling in astrocytes. Their mechanisms of action converge on down-regulating hyperglutamatergic excitotoxicity-and caspase-I-induced pyroptosis. They are therfore in a position to downregulate inflammatory-related… CONTINUE READING

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