PRESCRIBED FENOTEROL AND DEATH FROM ASTHMA IN NEW ZEALAND, 1981-83; CASE-CONTROL STUDY

@article{Crane1989PRESCRIBEDFA,
  title={PRESCRIBED FENOTEROL AND DEATH FROM ASTHMA IN NEW ZEALAND, 1981-83; CASE-CONTROL STUDY},
  author={Julian Crane and A. Flatt and Rodney Jackson and Michael Ball and Neil Pearce and Carl D. Burgess and Terence Kwong and Richard Beasley},
  journal={The Lancet},
  year={1989},
  volume={333},
  pages={917-922}
}
A case-control study was conducted to examine the hypothesis that fenoterol by metered dose inhaler (MDI) increases the risk of death in patients with asthma. The case group comprised 117 patients aged 5-45 who died of asthma between August, 1981, and July, 1983. For each case, 4 controls, matched for age and ethnic group, were selected from asthma admissions to hospitals to which the cases themselves would have been admitted, had they survived. The relative risk of asthma death in patients… 
Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81.
TLDR
Findings from this case-control study add further support to the hypothesis that inhaled fenoterol increases the risk of death in patients with severe asthma.
Prescribed fenoterol and death from asthma in New Zealand, 1981-7: a further case-control study.
TLDR
Findings address the major criticisms of previous case-control studies of this issue, and add support to the hypothesis that inhaled fenoterol increases the risk of death in patients with severe asthma.
Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81.
TLDR
A case-control study suggesting that fenoterol was associated with risk of death in patients with severe asthma in New Zealand did not accept the validity of the first report because of several problems in methods and analysis.
Prescribed drug therapy and near-fatal asthma attacks.
TLDR
The findings of this case-control study are consistent with the hypothesis that fenoterol increases the risk of near-fatal asthma attacks, and that they complement previous findings on fatal asthma attacks.
A case-control study of asthma death and life-threatening attack: their possible relationship with prescribed drug therapy in Japan.
TLDR
The results suggested that beta2-agonists administered by a MDI might have increased the risk of asthma death and LTA in Japan because the magnitude of the effect was similar to that reported in other countries.
Confounding by severity does not explain the association between fenoterol and asthma death
TLDR
In patients whose asthma is severe enough to require hospital admission, there is little evidence that fenoterol was selectively prescribed to the more severe patients and that the findings in the most severe sub‐groups effectively exclude the ‘confounding by severity’ hypothesis as an explanation for the recent case‐control findings.
Bronchodilator treatment and asthma death: a new analysis of a British case-control study.
TLDR
In a population based case-control study where prescription of LABA without concomitant ICS was uncommon there was no evidence of an overall association between LABA and asthma death and no coherent evidence of effect modification by social deprivation.
Albuterol and deaths from asthma in New Zealand from 1969 to 1976: A case‐control study
TLDR
Albuterol was not associated with deaths from asthma after its introduction in New Zealand, and the findings indicate that patients with unstable asthma were switched to fenoterol after itsintroduction.
Case-control study of salmeterol and near-fatal attacks of asthma.
TLDR
The findings of this case-control study suggest that the use of salmeterol by patients with chronic severe asthma is not associated with a significantly increased risk of a near-fatal attack of asthma.
Asthma and the beta agonist debate.
TLDR
It is concluded that the strong association between the use of inhaled /3 agonists and asthma mortality is confined primarily to the useof these drugs in excess of recommended limits.
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