PREPARATIVE LC AND NON-POROUS SILICA CHROMATOGRAPHY AS USEFUL TOOLS IN LARGE SCALE DENDRIMER SYNTHESIS

@inproceedings{Chao2002PREPARATIVELA,
  title={PREPARATIVE LC AND NON-POROUS SILICA CHROMATOGRAPHY AS USEFUL TOOLS IN LARGE SCALE DENDRIMER SYNTHESIS},
  author={Helen M. Chao and Charles John Shaw and James Edward Hanson},
  year={2002}
}
ABSTRACT The convergent synthesis of poly(benzyl ether) dendrimers was published by Frechet et al.[1] However, the coupling of the lower generation bromide with the 3,5-dihydroxy benzyl alcohol (monomer) involved the use of triphenylphosphine. The purification of higher generation dendrimers was difficult because triphenylphosphine was not easily separated from the desired product. A different approach was studied in our laboratory. A mesylate intermediate was developed, followed by the… CONTINUE READING