PREPARATION AND EVALUATION OF MONOLITHIC TRANSDERMAL THERAPEUTIC SYSTEMS CONTAINING FENOPROFEN FOR THE TREATMENT OF ARTHRITIS

@inproceedings{Manjula2012PREPARATIONAE,
  title={PREPARATION AND EVALUATION OF MONOLITHIC TRANSDERMAL THERAPEUTIC SYSTEMS CONTAINING FENOPROFEN FOR THE TREATMENT OF ARTHRITIS},
  author={Dotherabandi Manjula and Somashekar S. Shyale and J Josephine Leno Jenita},
  year={2012}
}
Monolithic transdermal films of Fenoprofen were prepared to avoid hepatic first pass effect by using hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) by solvent casting method. Dibutyl phthalate (DBP) was used as plasticizer. D-limonene and oleic acid were used as permeation enhancers. The formulations were evaluated for physical appearance, thickness uniformity, weight uniformity, drug content uniformity and water vapour transmission rate. In further study the effect of… CONTINUE READING

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