PREPARATION, IN VITRO AND IN VIVO EVALUATION OF ORAL INDOMETHACIN-HP-B- CYCLODEXTRIN LOADED CHITOSAN NANOPARTICLES

@inproceedings{ELFEKYa2013PREPARATIONIV,
  title={PREPARATION, IN VITRO AND IN VIVO EVALUATION OF ORAL INDOMETHACIN-HP-B- CYCLODEXTRIN LOADED CHITOSAN NANOPARTICLES},
  author={Gina S. EL-FEKYa and Sally T. EL-BANNAb},
  year={2013}
}
The low solubility and the irritant effect of oral indomethacin (IND) on the lining of the stomach limit to a great extent its therapeutic potential. The aim of this study is first; to enhance the solubility of IND through complexation with hydroxyl propyl beta cyclodextrin (HP-β-CD) second, to incorporate the complex onto chitosan (CS) nanoparticles (NP), formed through ionic gelation, in order to control the drug release and to enhance its permeability and finally; to coat the complex loaded… CONTINUE READING

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