PRENATAL BRAIN DAMAGE AND PLACENTAL INFARCTION –AN AUTOPSY STUDY

@article{Burke1995PRENATALBD,
  title={PRENATAL BRAIN DAMAGE AND PLACENTAL INFARCTION –AN AUTOPSY STUDY},
  author={Christopher J. Burke and Anthony E. G. Tannenberg},
  journal={Developmental Medicine \& Child Neurology},
  year={1995},
  volume={37}
}
The histopathological abnormalities seen at autopsy in the brains and corresponding placentas of a consecutive four‐year series of stillborn infants are presented. After excluding stillbirths with major cerebral malformations, the brains of 175 cases and the corresponding placentas in 165 cases were available for assessment. 70 of the 175 brains (40 per cent) showed microscopic evidence of ischaemie cerebral injury, using a combination of haematoxylin‐eosin and glial fibrillary acid protein… 
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The correspondence between the time courses of histological features of chorioamnionitis, neuronal karyorrhexis, and thymic involution points to irreversible central nervous system injury being common 12–48 hours prior to in utero demise.
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Antenatal brain injury in third trimester neonates with severe congenital anomalies: an autopsy study
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Placentas from infants with NI can contribute to an understanding of the mechanisms that contribute to NI at term, and logistic regression findings suggest that placental pathology can help understand these mechanisms.
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    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2014
TLDR
Findings indicate brain injury predated the time period immediately before delivery in 9 of 10 fetuses, and in the fetuses with established brain injury the onset of acute illness was possibly >72 h before delivery.
Placental fetal thrombotic vasculopathy is associated with neonatal encephalopathy.
TLDR
The absence of significant clinical antenatal factors supports the value of placental examination in the investigation of infants with NE, and features of infection, thrombosis, and disturbed uteroplacental flow are significant independent factors in the etiology of NE in this study.
Correlation of Placental Pathology with Perinatal Brain Injury.
TLDR
Findings in the placenta can play an important role in documenting sentinel events, uncovering clinically silent thromboinflammatory disease processes, revealing developmental alterations in functional reserve, and suggesting alterations in related maternal and fetal physiology.
Fetal Central Nervous System Injury in Third Trimester Stillbirth: A Clinicopathologic Study of 63 Cases
TLDR
Brain injury, most frequently established gray matter damage, is seen in the majority of stillborn infants with unexplained demise, indicating that the brain injury predates the period immediately before death.
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