PREDICTING INHIBITION OF DEHYDROQUINATE SYNTHASE

@inproceedings{Piehler1991PREDICTINGIO,
  title={PREDICTING INHIBITION OF DEHYDROQUINATE SYNTHASE},
  author={Lars T. Piehler and Jean Luc Montchamp and John W. Frost and Charles J. Manly},
  year={1991}
}
Abstract Computational molecular superimposition studies predicted that a carbaphosphonate would be a likely inhibitor of 3-dehydroquinate synthase prior to the molecule's synthesis. Mechanistic implications of the enzyme inhibition subsequently observed are discussed.