PRECLINICAL STUDY: Long‐lasting tolerance to alcohol following a history of dependence

  title={PRECLINICAL STUDY: Long‐lasting tolerance to alcohol following a history of dependence},
  author={R. Rimondini and W. H. Sommer and R. Dall'olio and M. Heilig},
  journal={Addiction Biology},
Tolerance to alcohol effects is one of the defining features of clinical alcohol dependence. Here, we hypothesized that the post‐dependent state may include tolerance to sedative‐hypnotic alcohol actions. To address this question, we used a recently developed animal model in which repeated cycles of alcohol intoxication and withdrawal trigger long‐lasting behavioral plasticity. This animal model shares important features with the clinical condition. Animals were exposed to 7 weeks of… Expand
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