PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.

@article{Harms2015PRDM16BM,
  title={PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.},
  author={Matthew J. Harms and H. Lim and Y. Ho and Suzanne N. Shapira and Jeff Ishibashi and S. Rajakumari and D. Steger and M. Lazar and Kyoung-Jae Won and P. Seale},
  journal={Genes & development},
  year={2015},
  volume={29 3},
  pages={
          298-307
        }
}
PR (PRD1-BF1-RIZ1 homologous) domain-containing 16 (PRDM16) drives a brown fat differentiation program, but the mechanisms by which PRDM16 activates brown fat-selective genes have been unclear. Through chromatin immunoprecipitation (ChIP) followed by deep sequencing (ChIP-seq) analyses in brown adipose tissue (BAT), we reveal that PRDM16 binding is highly enriched at a broad set of brown fat-selective genes. Importantly, we found that PRDM16 physically binds to MED1, a component of the Mediator… Expand
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