PRC2 is dispensable for HOTAIR‐mediated transcriptional repression

PRC2 is dispensable for HOTAIR‐mediated transcriptional repression},
  author={Manuela Portoso and Roberta Ragazzini and Živa Bren{\vc}i{\vc} and Arianna Moiani and Audrey Michaud and Ivaylo Vassilev and Michel Wassef and Nicolas Servant and Bruno Sargueil and Rapha{\"e}l Margueron},
  booktitle={The EMBO journal},
Long non-coding RNAs (lncRNAs) play diverse roles in physiological and pathological processes. Several lncRNAs have been suggested to modulate gene expression by guiding chromatin-modifying complexes to specific sites in the genome. However, besides the example of Xist, clear-cut evidence demonstrating this novel mode of regulation remains sparse. Here, we focus on HOTAIR, a lncRNA that is overexpressed in several tumor types and previously proposed to play a key role in gene silencing through… CONTINUE READING
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Long no-coding RNA HOTAIR reprograms RNA state to promote cancer metastasis

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