PRC2 binds to active promoters and contacts nascent RNAs in embryonic stem cells

@inproceedings{Kaneko2013PRC2BT,
  title={PRC2 binds to active promoters and contacts nascent RNAs in embryonic stem cells},
  author={Syuzo Kaneko and Jinsook Son and Steven R. S. Shen and Danny F Reinberg and Roberto Bonasio},
  booktitle={Nature Structural &Molecular Biology},
  year={2013}
}
EZH2 is the catalytic subunit of PRC2, a central epigenetic repressor essential for development processes in vivo and for the differentiation of embryonic stem cells (ESCs) in vitro. The biochemical function of PRC2 in depositing repressive H3K27me3 marks is well understood, but how it is regulated and directed to specific genes before and during differentiation remains unknown. Here, we report that PRC2 binds at low levels to a majority of promoters in mouse ESCs, including many that are… CONTINUE READING
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