PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation.

@article{CruzMolina2017PRC2FT,
  title={PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation.},
  author={Sara Cruz-Molina and Patricia Respuela and Christina Tebartz and Petros Kolovos and Milos Nikolic and Raquel Fueyo and Wilfred F J van Ijcken and Frank G. Grosveld and Peter Frommolt and Hisham Bazzi and Alvaro Rada-Iglesias},
  journal={Cell stem cell},
  year={2017},
  volume={20 5},
  pages={689-705.e9}
}
Poised enhancers marked by H3K27me3 in pluripotent stem cells have been implicated in the establishment of somatic expression programs during embryonic stem cell (ESC) differentiation. However, the functional relevance and mechanism of action of poised enhancers remain unknown. Using CRISPR/Cas9 technology to engineer precise genetic deletions, we demonstrate that poised enhancers are necessary for the induction of major anterior neural regulators. Interestingly, circularized chromosome… CONTINUE READING
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