PRC1 cooperates with CLASP1 to organize central spindle plasticity in mitosis.

@article{Liu2009PRC1CW,
  title={PRC1 cooperates with CLASP1 to organize central spindle plasticity in mitosis.},
  author={Jing Liu and Zhikai Wang and Kai Jiang and Liangyu Zhang and Lingli Zhao and Shasha Hua and Feng Yan and Yong Yang and Dongmei Wang and Chuanhai Fu and Xia Ding and Zhen Guo and Xuebiao Yao},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 34},
  pages={23059-71}
}
During cell division, chromosome segregation is governed by the interaction of spindle microtubules with the kinetochore. A dramatic remodeling of interpolar microtubules into an organized central spindle between the separating chromatids is required for the initiation and execution of cytokinesis. Central spindle organization requires mitotic kinesins, microtubule-bundling protein PRC1, and Aurora B kinase complex. However, the precise role of PRC1 in central spindle organization has remained… CONTINUE READING

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