PRAK, a novel protein kinase regulated by the p38 MAP kinase.

  title={PRAK, a novel protein kinase regulated by the p38 MAP kinase.},
  author={Liguo New and Yu Jiang and Meijuan Zhao and Kang Liu and Weijia Zhu and Lisa Flood and Yukio Kato and Graham C N Parry and Jiahuai Han},
  journal={The EMBO journal},
  volume={17 12},
We have identified and cloned a novel serine/ threonine kinase, p38-regulated/activated protein kinase (PRAK). PRAK is a 471 amino acid protein with 20-30% sequence identity to the known MAP kinase-regulated protein kinases RSK1/2/3, MNK1/2 and MAPKAP-K2/3. PRAK was found to be expressed in all human tissues and cell lines examined. In HeLa cells, PRAK was activated in response to cellular stress and proinflammatory cytokines. PRAK activity was regulated by p38alpha and p38beta both in vitro… CONTINUE READING
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Characterization of the structure and function of the fourth member of p38 group MAP kinase-p38δ

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