PRAC2: A new gene expressed in human prostate and prostate cancer

  title={PRAC2: A new gene expressed in human prostate and prostate cancer},
  author={P{\"a}r Olsson and Akira Motegi and Tapan K Bera and Byungkook Lee and Ira Pastan},
  journal={The Prostate},
The database of human Expressed Sequence Tags was previously used to identify PRAC (Prostate 47:125–131, 2001), a novel gene specifically expressed in human prostate, prostate cancer, rectum, and distal colon. In this report, we have identified PRAC2, another gene with a similar expression pattern that is located adjacent to the original PRAC gene on chromosome 17q21.3. 

Expression analysis onto microarrays of randomly selected cDNA clones highlights HOXB13 as a marker of human prostate cancer

Quantitative RT–PCR demonstrated the specificity of expression of HOXB13 in prostate tissue and revealed its ubiquitous expression in a series of 37 primary prostate cancers and 20 normal prostates, demonstrating the utility of this expression-microarray approach in hunting for new markers of individual human cancer types.

Aberrant expression of the PRAC gene in prostate cancer.

The findings suggest that the pathogenesis of PCa may be due to the expression levels of PRAC protein, and this protein can serve as a potential biomarker for the management ofPCa.

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Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes

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Results indicate distinct patterns of DNA methylation, independent of CIMP genes, in adenomas of the right and left colon.



GDEP, a new gene differentially expressed in normal prostate and prostate cancer †

The database of human expressed sequence tags (dbEST) is a potential source for the identification of tissue specific genes from cDNA libraries from different tissues cell types and tumors.

PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach

  • T. BeraR. Maitra I. Pastan
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
Analysis of the amino acid sequence of PATE shows that it has structural similarities to a group of proteins known as three-finger toxins, which includes the extracellular domain of the type β transforming growth factor receptor, which makes it a potential candidate for the immunotherapy of prostate cancer.

Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis.

The computer analysis identified 15 promising genes that were previously unidentified that could be useful in the targeted therapy of prostate cancer and three were found to be prostate specific.

PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.

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Localization of potential tumor suppressor loci to a < 2 Mb region on chromosome 17q in human prostate cancer.

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To understand better the genetic basis of the clonal evolution of prostate carcinoma, the authors analyzed the pattern of allelic loss in 25 matched primary and metastatic prostate tumors.

High expression of a specific T-cell receptor γ transcript in epithelial cells of the prostate

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