PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases.

@article{Croci2014PPNDSIM,
  title={PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases.},
  author={Romina Croci and Delia Tarantino and M. T. Milani and Margherita Pezzullo and Jacques Rohayem and Martino Bolognesi and Eloise Mastrangelo},
  journal={FEBS letters},
  year={2014},
  volume={588 9},
  pages={1720-5}
}
Norovirus (NV) is a major cause of gastroenteritis worldwide. Antivirals against such important pathogens are on demand. Among the viral proteins that orchestrate viral replication, RNA-dependent-RNA-polymerase (RdRp) is a promising drug development target. From an in silico-docking search focused on the RdRp active site, we selected the compound PPNDS, which showed low micromolar IC50vs. murine NV-RdRp in vitro. We report the crystal structure of the murine NV-RdRp/PPNDS complex showing that… CONTINUE READING

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