PPM1H is a p27 phosphatase implicated in trastuzumab resistance.

  title={PPM1H is a p27 phosphatase implicated in trastuzumab resistance.},
  author={Si Tuen Lee-Hoeflich and Thinh Q Pham and Don Dowbenko and Xander Munroe and James Chun-Yin Lee and Li Li and Wei Zhou and Peter M. Haverty and Kanan Pujara and Jeremy Stinson and Sara M Chan and Jeffrey R Eastham-Anderson and Ajay Pandita and Somasekar Seshagiri and Klaus P. Hoeflich and Gulisa Turashvili and Karen A. Gelmon and Samuel Aparicio and David P. Davis and Mark X. Sliwkowski and Howard M. Stern},
  journal={Cancer discovery},
  volume={1 4},
The HER2 oncogene is overexpressed or amplified in 20% of breast cancers. HER2-positive cancer historically portends a poor prognosis, but the HER2-targeted therapy trastuzumab mitigates this otherwise ominous distinction. Nevertheless, some patients suffer disease recurrence despite trastuzumab, and metastatic disease remains largely incurable due to innate and acquired resistance. Thus, understanding trastuzumab resistance remains an unmet medical need. Through RNA interference screening, we… CONTINUE READING

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