PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.

  title={PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.},
  author={Wenjing Sun and Yonghao Yu and Gianpietro Dotti and Tao Shen and Xiaojie Tan and Barbara Savoldo and Amy Kun Pass and Meijin Chu and Dekai Zhang and Xiongbin Lu and Songbin Fu and Xia Lin and Jianhua Yang},
  journal={Cellular signalling},
  volume={21 1},
IKKbeta serves as a central intermediate signaling molecule in the activation of the NF-kappaB pathway. However, the precise mechanism for the termination of IKKbeta activity is still not fully understood. Using a functional genomic approach, we have identified two protein serine/threonine phosphatases, PPM1A and PPM1B, as IKKbeta phosphatases. Overexpression of PPM1A or PPM1B results in dephosphorylation of IKKbeta at Ser177 and Ser181 and termination of IKKbeta-induced NF-kappaB activation… CONTINUE READING
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