PPM1A Phosphatase is Involved in Regulating Pregnane Xenobiotic Receptor Mediated Cytochrome P450 3A4 Gene Expression

@inproceedings{Flannery2014PPM1API,
  title={PPM1A Phosphatase is Involved in Regulating Pregnane Xenobiotic Receptor Mediated Cytochrome P450 3A4 Gene Expression},
  author={Patrick J. Flannery},
  year={2014}
}
The liver is the most important organ of drug metabolism and plays a major role in the detoxification of both endobiotics and xenobiotics. The process of drug metabolism is undertaken in three distinct phases. Cytochromes p450s (CYPs), enzymes belonging to the first phase of drug metabolism, are vital to drug metabolism. In particular, cytochrome p450 3A4 (CYP3A4), which metabolizes 60% of FDA approved drugs, plays a crucial role in drug metabolism. The human pregnane xenobiotic receptor (hPXR… CONTINUE READING

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