PPI-Refractory GERD: an Intriguing, Probably Overestimated, Phenomenon.

@article{Baldi2015PPIRefractoryGA,
  title={PPI-Refractory GERD: an Intriguing, Probably Overestimated, Phenomenon.},
  author={Fabio Baldi},
  journal={Current gastroenterology reports},
  year={2015},
  volume={17 7},
  pages={
          451
        }
}
Proton-pump inhibitors (PPIs) are still a cornerstone of pharmacologic treatment for gastroesophageal reflux disease (GERD) because of their unquestionable efficacy in reducing the acid component of refluxate. However, their extensive use in the general population has revealed a subset of patients who are unsatisfied with these agents. These patients are considered unresponsive to PPIs, and this emerging phenomenon, defined as refractoriness to PPIs, may have a prevalence ranging from 10 to 40… CONTINUE READING
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