PPEY motif within the rabies virus (RV) matrix protein is essential for efficient virion release and RV pathogenicity.

@article{Wirblich2008PPEYMW,
  title={PPEY motif within the rabies virus (RV) matrix protein is essential for efficient virion release and RV pathogenicity.},
  author={Christoph Wirblich and Gene S. Tan and Amy B. Papaneri and Peter J Godlewski and Jan Marc Orenstein and Ronald N Harty and Matthias J Schnell},
  journal={Journal of virology},
  year={2008},
  volume={82 19},
  pages={9730-8}
}
Late (L) domains containing the highly conserved sequence PPXY were first described for retroviruses, and later research confirmed their conservation and importance for efficient budding of several negative-stranded RNA viruses. Rabies virus (RV), a member of the Rhabdoviridae family, contains the sequence PPEY (amino acids 35 to 38) within the N terminus of the matrix (M) protein, but the functions of this potential L-domain in the viral life cycle, viral pathogenicity, and immunogenicity have… CONTINUE READING
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