• Corpus ID: 17353563

PPARs of the Heart Three Is a

  title={PPARs of the Heart Three Is a},
  author={Daniel P. Kelly},
The peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated transcription factors within the broad nuclear receptor superfamily. The PPAR family includes three members encoded by distinct genes: , / , and (see reviews1,2). PPAR was originally identified as the intracellular receptor for a class of nongenotoxic rodent hepatocarcinogens, which includes the hypolipidemic drug clofibrate, a potent inducer of hepatic peroxisomal proliferation and hypolipidemic agent. The… 


A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport
The results suggest that PPARδ agonists may be effective drugs to increase reverse cholesterol transport and decrease cardiovascular disease associated with the metabolic syndrome X.
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
This work has shown that direct expression of PPAR mRNAs in the absence of a specific carrier gene results in down-regulation in the activity of other PPARs, and these properties are consistent with those of a “spatially aggregating substance”.
PPAR signaling in the control of cardiac energy metabolism.
Reactivation of Peroxisome Proliferator-activated Receptor α Is Associated with Contractile Dysfunction in Hypertrophied Rat Heart*
PPARα activation blocked skeletal α-actin induction, reversed the down-regulation of measured PPARα-regulated genes in the hypertrophied heart, and prevented substrate switching, resulting in severe depression of cardiac power and efficiency in the hypertension-induced heart.
Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart.
Results suggest a transcriptional mechanism for decreased fatty oxidation and increased reliance of the heart for glucose during hypoxia, and PPARalpha-regulated gene expression is decreased in two models of Hypoxia in vivo.
Growth, Adipose, Brain, and Skin Alterations Resulting from Targeted Disruption of the Mouse Peroxisome Proliferator-Activated Receptor β(δ)
These results are the first to provide in vivo evidence of significant roles for PPARβ in development, myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.
PPARalpha is a critical regulator of myocardial fatty acid uptake and utilization, activation of cardiac PPARalpha regulatory pathways results in a reciprocal repression of glucose uptake and usage pathways, and derangements in myocardian energy metabolism typical of the diabetic heart can become maladaptive, leading to cardiomyopathy.
Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth.
Results indicate that during cardiac hypertrophic growth, PPARalpha is deactivated at several levels, leading to diminished capacity for myocardial lipid and energy homeostasis.
Peroxisome Proliferator-Activated Receptor (PPAR) (cid:1) and PPAR (cid:2) / (cid:3) , but not PPAR (cid:4) , Modulate the Expression of Genes Involved in Cardiac Lipid Metabolism
PPAR plays a prominent role in the regulation of cardiac lipid metabolism, thereby warranting further research into the role of PPAR ( cid:2) / (cid:3) in cardiac disease.
Peroxisome Proliferator-Activated Receptor &ggr; Activators Inhibit Cardiac Hypertrophy in Cardiac Myocytes
It is suggested that PPAR&ggr; activators may regulate cardiomyocyte hypertrophy at least partially through the NF-&kgr;B pathway.