PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways

@inproceedings{Camps2012PPARsIR,
  title={PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways},
  author={Jordi Camps and Anabel Garc{\'i}a-Heredia and Anna Rull and Carlos Jos{\'e} Alonso-Villaverde and Gerard Aragon{\`e}s and Ra{\'u}l Beltr{\'a}n-Deb{\'o}n and Esther Rodr{\'i}guez-Gallego and Jorge Joven},
  booktitle={PPAR research},
  year={2012}
}
The paraoxonase (PON) group of enzymes, composed of PON1, PON2, and PON3, play an important role in decreasing oxidative stress by degrading lipid peroxides. PON1 synthesis is upregulated by PPAR. Several pharmacological compounds (acting as antioxidants and, hence, atheroprotective) stimulate both PPAR activity and PON1 expression. Recent evidence suggests that PON1 and the monocyte chemoattractant protein-1 (MCP-1) are involved in coordinating the inflammatory response in damaged tissues… CONTINUE READING

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