PPARs and the complex journey to obesity

  title={PPARs and the complex journey to obesity},
  author={Ronald M Evans and Grant D Barish and Y Wang},
  journal={Nature Medicine},
Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling have revolutionized our understanding of fat and sugar metabolism and their intimate link. The three 'lipid-sensing' peroxisome proliferator–activated receptors (PPAR-α, PPAR-γ and PPAR-δ) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis… CONTINUE READING
Highly Influential
This paper has highly influenced 41 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS