PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials

@inproceedings{Vamecq2012PPARsIW,
  title={PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials},
  author={Joseph Vamecq and J M Colet and Jean Jacques Vanden Eynde and Gilbert Briand and Nicole Porchet and St{\'e}phane Rocchi},
  booktitle={PPAR research},
  year={2012}
}
The metabolic/cell signaling basis of Warburg's effect ("aerobic glycolysis") and the general metabolic phenotype adopted by cancer cells are first reviewed. Several bypasses are adopted to provide a panoramic integrated view of tumoral metabolism, by attributing a central signaling role to hypoxia-induced factor (HIF-1) in the expression of aerobic glycolysis. The cancer metabolic phenotype also results from alterations of other routes involving ras, myc, p53, and Akt signaling and the… CONTINUE READING
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