• Medicine
  • Published in The Journal of nutrition 2008

PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells.

@article{Allred2008PPARgamma1AA,
  title={PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells.},
  author={Clinton David Allred and Dominique R. Talbert and R. Chase Southard and Xin Wang and Michael W. Kilgore},
  journal={The Journal of nutrition},
  year={2008},
  volume={138 2},
  pages={
          250-6
        }
}
Diets high in (n-3) PUFA decrease colon cancer development and suppress colon tumor growth, but the molecular mechanism through which these compounds act is largely unknown. We sought to determine whether PPARgamma1 serves as a molecular link between the physiological actions of eicosapentaenoic acid (EPA) in human colon cancer cells (HT-29). At nutritionally relevant concentrations, EPA stimulated a PPAR response element (PPRE) reporter assay in a dose-responsive manner in HT-29 cells… CONTINUE READING

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