PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease.

@article{Chiang2012PPARgammaRO,
  title={PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease.},
  author={Ming-Chang Chiang and Yijuang Chern and R N Huang},
  journal={Neurobiology of disease},
  year={2012},
  volume={45 1},
  pages={322-8}
}
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. The resultant mutant Htt protein (mHtt) forms aggregates in the brain (e.g., cortex and striatum), and causes devastating neuronal degeneration. Transcriptional dysfunction caused by mHtt is critical for HD. We recently demonstrated that a crucial transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) played a major function in the… CONTINUE READING