PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

@article{Kershaw2007PPARgammaRA,
  title={PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.},
  author={Erin E Kershaw and Michael Schupp and Hong-Ping Guan and Noah P. Gardner and Mitchell A Lazar and Jeffrey S. Flier},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={293 6},
  pages={E1736-45}
}
Peroxisome proliferator-activated receptor-gamma (PPARgamma) regulates adipocyte genes involved in adipogenesis and lipid metabolism and is the molecular target for thiazolidinedione (TZD) antidiabetic agents. Adipose triglyceride lipase (ATGL) is a recently described triglyceride-specific lipase that is induced during adipogenesis and remains highly expressed in mature adipocytes. This study evaluates the ability of PPARgamma to directly regulate ATGL expression in adipocytes in vitro and in… CONTINUE READING
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