PPARgamma promotes mannose receptor gene expression in murine macrophages and contributes to the induction of this receptor by IL-13.

@article{Coste2003PPARgammaPM,
  title={PPARgamma promotes mannose receptor gene expression in murine macrophages and contributes to the induction of this receptor by IL-13.},
  author={Agn{\`e}s Coste and Marc Dubourdeau and Marie Denise Linas and Sophie Cassaing and J. C. Lepert and Patricia Balard and Sandrine Chalmeton and J. J. Bernad and Claudine Orfila and J L S{\'e}gu{\'e}la and Bernard Pipy},
  journal={Immunity},
  year={2003},
  volume={19 3},
  pages={329-39}
}
Macrophage mannose receptor (MMR) is an important component of the innate immune system implicated in host defense against microbial infections such as candidiasis and in antigen presentation. We demonstrate here that the MMR expression is induced in mouse peritoneal macrophages following exposure to PPARgamma ligands or to interleukine-13 (IL-13) via a PPARgamma signaling pathway. Ligand activation of the PPARgamma in macrophages promotes uptake, killing of Candida albicans, and reactive… CONTINUE READING