PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cells.


Although thiazolidinediones (TZD) effectively improve hyperglycemia and increase adiponectin, a proinsulin-sensitizing adipokine, they also increase adipogenesis via peroxisome proliferator-activated receptor (PPAR)γ induction, which may be undesirable. Recent safety concerns about some TZD have prompted the search for next generation agents that can… (More)
DOI: 10.1210/en.2011-0225