PPARgamma in placental angiogenesis.

  title={PPARgamma in placental angiogenesis.},
  author={Karim Nadra and Laure Quignodon and Chiara Sardella and Elisabeth Joye and Antonio Mucciolo and Roman Chrast and B{\'e}atrice Desvergne},
  volume={151 10},
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor involved in diverse biological processes including adipocyte differentiation, glucose homeostasis, and inflammatory responses. Analyses of PPARγ knockout animals have been so far preempted by the early embryonic death of PPARγ-/- embryos as a consequence of the severe alteration of their placental vasculature. Using Sox2Cre/PPARγL2/L2 mice, we obtained fully viable PPARγ-null mice through specific and total epiblastic… CONTINUE READING
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