PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages.

@article{Welch2003PPARgammaAP,
  title={PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages.},
  author={John S. Welch and Mercedes Ricote and Taro E. Akiyama and Frank J. Gonzalez and Christopher K. Glass},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 11},
  pages={6712-7}
}
Natural and synthetic agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma) regulate adipocyte differentiation, glucose homeostasis, and inflammatory responses. Although effects on adipogenesis and glucose metabolism are genetically linked to PPARgamma, the PPARgamma dependence of antiinflammatory responses of these substances is less clear. Here, we have used a combination of mRNA expression profiling and conditional disruption of the PPARgamma gene in mice to… CONTINUE READING