PPARgamma/RXRalpha heterodimers control human trophoblast invasion.

  title={PPARgamma/RXRalpha heterodimers control human trophoblast invasion.},
  author={Anne Tarrade and Kristina Schoonjans and Laetitia Pavan and Johan Auwerx and C{\'e}cile Rochette-Egly and Dani{\`e}le Evain-Brion and Thierry Fournier},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={86 10},
The ligand-dependent nuclear receptors PPARgamma and RXRalpha/beta were recently determined to be essential for murine placental development and trophoblast differentiation. In the current study we examined the expression and role of the PPARgamma/RXRalpha heterodimers in human invasive trophoblasts. We first report that in human first trimester placenta, PPARgamma and RXRalpha are highly expressed in cytotrophoblasts at the feto-maternal interface, especially in the extravillous… CONTINUE READING
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