PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.

@article{Rival2002PPARalphaAP,
  title={PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.},
  author={Yves Rival and Nathalie Ben{\'e}teau and Thierry Taillandier and Myl{\`e}ne Pezet and Elisabeth Dupont-Passelaigue and Jean François Patoiseau and Didier Junqu{\'e}ro and F. C. Colpaert and Andr{\'e} Delhon},
  journal={European journal of pharmacology},
  year={2002},
  volume={435 2-3},
  pages={143-51}
}
Endothelium injury is a primary event in atherogenesis, which is followed by monocyte infiltration, macrophage differentiation, and smooth muscle cell migration. Peroxisome proliferator-activated receptors (PPARs) are transcription factors now recognized as important mediators in the inflammatory response. The aim of this study was to develop a human endothelial model to evaluate anti-inflammatory properties of PPAR activators. PPAR proteins (alpha, delta and gamma) are expressed in EAhy926… CONTINUE READING

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