PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.


BACKGROUND AND PURPOSE Nitric oxide (NO) production through the inducible nitric oxide synthase (iNOS) pathway is increased in response to pro-inflammatory cytokines and bacterial products. In inflammation, NO has pro-inflammatory and regulatory effects. Peroxisome proliferator-activated receptors (PPARs), members of the nuclear steroid receptor superfamily… (More)


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